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phosphoatm ser1981  (Cell Signaling Technology Inc)


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    Cell Signaling Technology Inc phosphoatm ser1981
    Phosphoatm Ser1981, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 96/100, based on 281 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/anti+phosphoatm+ser1981+antibody/Phospho-ATM+(Ser1981)+Rabbit+mAb/pm41888112-515-55-57
    Average 96 stars, based on 281 article reviews
    phosphoatm ser1981 - by Bioz Stars, 2026-11
    96/100 stars

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    Polymer:

    Article Title: p53-dependent crosstalk between DNA replication integrity and redox metabolism mediated through a NRF2-PARP1 axis
    Article Snippet: Dimethyl fumarate (Sigma Aldrich, 242926), G6PDi-1 (Sigma Aldrich, SML2980) and G6PD activator AG1 (MedchemExpress, HY-123962). .. Primary antibodies used were: anti-γH2AX antibodies (Abcam, ab2893 and Millipore, JBW301), anti-NRF2 antibody (Santa Cruz, sc-365949), anti-Poly (ADP-Ribose) Polymer antibody [10H] (Abcam, ab14459), anti-PAR polyclonal antibody (Trevigen, 4336-BPC-100), anti-poly/mono-ADP ribose (E6F6A) antibody (CST, 83732), anti-GAPDH antibody (Abcam, ab9485), anti-Exonuclease 1 antibody (Thermo Fisher Scientific, A302-640A), anti-RRM2B antibody (Abcam, ab8105), anti-p53 antibody (DO-1) (Santa Cruz, sc-126), anti-HSP90 (AC88) (Abcam, ab13492), anti-BrdU antibody (BU1/75) (Abcam, ab6326), anti-RPA70 antibody (Abcam, ab79398), anti-RPA2(pS4/S8) (Novus Biologicals, NBP1-23017), anti-BrdU antibody (BD Biosciences, 347580), anti-β-Actin antibody (Sigma Aldrich, A5441), DYKDDDDK Tag antibody (Cell Signaling Technology, CST, #2368), anti-G6PD antibody (Santa Cruz, sc-373886), anti-CHK1 antibody (CST, 2345), anti-phosphoCHK1 (Ser317) antibody, (CST, 2344), anti-CHK2 antibody (CST, 2662), anti-phosphoCHK2 (Thr68) antibody (2197), anti-phosphoATM (Ser1981) antibody (CST, 4526), anti-ATR antibody (CST,2790) and anti-phosphoATR (Thr-1989) antibody (Abcam, ab223258). .. Primary antibodies used were: anti-γH2AX antibodies (Abcam, ab2893 and Millipore, JBW301), anti-NRF2 antibody (Santa Cruz, sc-365949), anti-Poly (ADP-Ribose) Polymer antibody [10H] (Abcam, ab14459), anti-PAR polyclonal antibody (Trevigen, 4336-BPC-100), anti-poly/mono-ADP ribose (E6F6A) antibody (CST, 83732), anti-GAPDH antibody (Abcam, ab9485), anti-Exonuclease 1 antibody (Thermo Fisher Scientific, A302-640A), anti-RRM2B antibody (Abcam, ab8105), anti-p53 antibody (DO-1) (Santa Cruz, sc-126), anti-HSP90 (AC88) (Abcam, ab13492), anti-BrdU antibody (BU1/75) (Abcam, ab6326), anti-RPA70 antibody (Abcam, ab79398), anti-RPA2(pS4/S8) (Novus Biologicals, NBP1-23017), anti-BrdU antibody (BD Biosciences, 347580), anti-β-Actin antibody (Sigma Aldrich, A5441), DYKDDDDK Tag antibody (Cell Signaling Technology, CST, #2368), anti-G6PD antibody (Santa Cruz, sc-373886), anti-CHK1 antibody (CST, 2345), anti-phosphoCHK1 (Ser317) antibody, (CST, 2344), anti-CHK2 antibody (CST, 2662), anti-phosphoCHK2 (Thr68) antibody (2197), anti-phosphoATM (Ser1981) antibody (CST, 4526), anti-ATR antibody (CST,2790) and anti-phosphoATR (Thr-1989) antibody (Abcam, ab223258).

    Article Title: p53-dependent crosstalk between DNA replication integrity and redox metabolism mediated through a NRF2-PARP1 axis.
    Article Snippet: Cell lines were ested for mycoplasma contamination before use. rugs enadione (Sigma Aldrich, M5625), Trolox (Sigma ldrich, 238813–1G), Tempo (Sigma Adrich, 176141- G), NAC (Sigma Adrich, A9165-5G), PARGi (Tocris ioscience, 00017273), Doxycycline (Clontech Laboratoies, 631311), Doxorubicin (Selleck Chem, S1208), ML385 Sigma Aldrich, SML 1833-5MG), Prexasertib HCL (Selleck hem, S7178), Aphidicolin (Sigma Aldrich, 89458), PHA67491 (CDC7i) (Selleck Chem, S2742), Roscovitine (Caliochem, 557364), Hydroxyurea (Sigma Aldrich, H8627), -Chloro-2 ′ -deoxyuridine (CIdU) (Sigma Aldrich, C6891), -Iodo-2 ′ -deoxyuridine (IdU) (Sigma Aldrich, I7125), PJ34 Calbiochem, 528150), VE-821 (Selleck Chemicals, S8007), laparib (AZD2281, Ku-0059436) (Selleck Chem, S1060), -ethynyl-2-deoxyuridine (Thermo Fisher Scientific, E10187). imethyl fumarate (Sigma Aldrich, 242926), G6PDi-1 (Sigma ldrich, SML2980) and G6PD activator AG1 (MedchemExress, HY-123962). .. Most compounds were reconstituted in MSO unless otherwise suggested. ntibodies rimary antibodies used were: anti- γH2AX antibodies (Abam, ab2893 and Millipore, JBW301), anti-NRF2 antibody Santa Cruz, sc-365949), anti-Poly (ADP-Ribose) Polymer anibody [10H] (Abcam, ab14459), anti-PAR polyclonal antiody (Trevigen, 4336-BPC-100), anti-poly / mono-ADP ribose E6F6A) antibody (CST, 83732), anti-GAPDH antibody (Abam, ab9485), anti-Exonuclease 1 antibody (Thermo Fisher cientific, A302-640A), anti-RRM2B antibody (Abcam, ab8105), anti-p53 antibody (DO-1) (Santa Cruz, sc-126), anti-HSP90 (AC88) (Abcam, ab13492), anti-BrdU antibody (BU1 / 75) (Abcam, ab6326), anti-RPA70 antibody (Abcam, ab79398), anti-RPA2(pS4 / S8) (Novus Biologicals, NBP123017), anti-BrdU antibody (BD Biosciences, 347580), antiβ-Actin antibody (Sigma Aldrich, A5441), DYKDDDDK Tag antibody (Cell Signaling Technology, CST, #2368), anti-G6PD antibody (Santa Cruz, sc-373886), anti-CHK1 antibody (CST, 2345), anti-phosphoCHK1 (Ser317) antibody, (CST, 2344), anti-CHK2 antibody (CST, 2662), anti-phosphoCHK2 (Thr68) antibody (2197), anti-phosphoATM (Ser1981) antibody (CST , 4526), anti-ATR antibody (CST ,2790) and antiphosphoATR (Thr-1989) antibody (Abcam, ab223258). .. Secondary antibodies used are: anti-Mouse IgG (HL) Alexa Fluor 488 (Thermo Fisher Scientific, A-11001), Donkey anti-Rat IgG (HL) Cy3 (Jackson ImmunoResearch Labs, 712-166- 153) and Goat polyclonal anti-Mouse IgG2a Alexa Fluor 350 (Thermo Fisher Scientific, A-21130).



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    Figure 8. Altered initiation of DNA damage response (DDR) in fibroid (F) stem cells: decreased DDR signal amplification and transduction following DNA double-strand break (DSB) induction. A, Western blots and corresponding densitometry of sensors of DNA DSBs, p-MRE11 (Ser676), MRE11, p-NBS1 (Ser343), and NBS1: untreated (UT), bleomycin-treated þ 1, 6, and 24 hours of recovery in n ¼ 4 patients. B, Western blots and corresponding densitometry of signal-transducing kinases, phosphorylated-Ataxia Telangiectasia Mutated (p-ATM; <t>Ser1981),</t> ATM, p-ATR (Ser1989), ATR: UT, bleomycin-treated þ 1, 6, and 24 hours of recovery in n ¼ 4 patients. C, Western blots and corresponding densitometry of effector kinases, p-CHK1 (Ser345), CHK1, p-CHK2 (Thr68), CHK2: UT, bleomycin-treated þ 1, 6, and 24 hours of recovery in n ¼ 4 patients. For each time point, the mean expression ratio in F: Myo was compared to 1 using a 2-sided 1-sample t test. Lines represent means + standard error of the meam. *P < .05. p-CHK1 indicates phosphorylated-Checkpoint Kinase 1; p-MRE11, phosphorylated-MRE11; p- NBS1, phosphorylated-Nijmegen Breakage Syndrome 1; p-ATR, phosphorylated-Ataxia Telangiectasia.
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    Figure 8. Altered initiation of DNA damage response (DDR) in fibroid (F) stem cells: decreased DDR signal amplification and transduction following DNA double-strand break (DSB) induction. A, Western blots and corresponding densitometry of sensors of DNA DSBs, p-MRE11 (Ser676), MRE11, p-NBS1 (Ser343), and NBS1: untreated (UT), bleomycin-treated þ 1, 6, and 24 hours of recovery in n ¼ 4 patients. B, Western blots and corresponding densitometry of signal-transducing kinases, phosphorylated-Ataxia Telangiectasia Mutated (p-ATM; Ser1981), ATM, p-ATR (Ser1989), ATR: UT, bleomycin-treated þ 1, 6, and 24 hours of recovery in n ¼ 4 patients. C, Western blots and corresponding densitometry of effector kinases, p-CHK1 (Ser345), CHK1, p-CHK2 (Thr68), CHK2: UT, bleomycin-treated þ 1, 6, and 24 hours of recovery in n ¼ 4 patients. For each time point, the mean expression ratio in F: Myo was compared to 1 using a 2-sided 1-sample t test. Lines represent means + standard error of the meam. *P < .05. p-CHK1 indicates phosphorylated-Checkpoint Kinase 1; p-MRE11, phosphorylated-MRE11; p- NBS1, phosphorylated-Nijmegen Breakage Syndrome 1; p-ATR, phosphorylated-Ataxia Telangiectasia.

    Journal: Reproductive sciences (Thousand Oaks, Calif.)

    Article Title: A Preliminary Study: Human Fibroid Stro-1 + /CD44 + Stem Cells Isolated From Uterine Fibroids Demonstrate Decreased DNA Repair and Genomic Integrity Compared to Adjacent Myometrial Stro-1 + /CD44 + Cells.

    doi: 10.1177/1933719118783252

    Figure Lengend Snippet: Figure 8. Altered initiation of DNA damage response (DDR) in fibroid (F) stem cells: decreased DDR signal amplification and transduction following DNA double-strand break (DSB) induction. A, Western blots and corresponding densitometry of sensors of DNA DSBs, p-MRE11 (Ser676), MRE11, p-NBS1 (Ser343), and NBS1: untreated (UT), bleomycin-treated þ 1, 6, and 24 hours of recovery in n ¼ 4 patients. B, Western blots and corresponding densitometry of signal-transducing kinases, phosphorylated-Ataxia Telangiectasia Mutated (p-ATM; Ser1981), ATM, p-ATR (Ser1989), ATR: UT, bleomycin-treated þ 1, 6, and 24 hours of recovery in n ¼ 4 patients. C, Western blots and corresponding densitometry of effector kinases, p-CHK1 (Ser345), CHK1, p-CHK2 (Thr68), CHK2: UT, bleomycin-treated þ 1, 6, and 24 hours of recovery in n ¼ 4 patients. For each time point, the mean expression ratio in F: Myo was compared to 1 using a 2-sided 1-sample t test. Lines represent means + standard error of the meam. *P < .05. p-CHK1 indicates phosphorylated-Checkpoint Kinase 1; p-MRE11, phosphorylated-MRE11; p- NBS1, phosphorylated-Nijmegen Breakage Syndrome 1; p-ATR, phosphorylated-Ataxia Telangiectasia.

    Article Snippet: Membranes were then incubated with primary antibodies (Supplemental Table S2): rabbit anti-phosphoATM (Ser1981), rabbit anti-ATM, rabbit anti-phospho-ATR (Thr1989), rabbit anti-ATR, rabbit anti-phospho-CHK1 (Ser345), mouse anti-CHK1, rabbit anti-phospho-CHK2 (Thr68), mouse anti-CHK2, rabbit anti-phospho-MRE11 (Ser676), rabbit anti-MRE11, rabbit anti-phospho-p95/NBS1 (Ser343), rabbit anti-p95/NBS1, and rabbit anti-RAD50 (all antibodies: Cell Signaling, Danvers, Massachusetts; 1:1000 dilution) overnight at 4 C in either 1% wt/vol nonfat dry milk or 1% BSA in 0.1% PBS-Tween (PBS-T) per antibody specification.

    Techniques: Amplification, Transduction, Western Blot, Expressing